CBG, General Health


By now, most readers have heard of THC (tetrahydrocannabinol) and CBD (cannabidiol) and their effects, but did you know that there are many similar compounds in the cannabis plant? A lesser-known cannabinoid called cannabigerol (CBG) may not be found in large quantities in most strains, but it is very interesting for you and your health for a number of reasons.

What is CBG?

Researchers believe that CBG is a mild antagonist of the CB1 receptor from the endocannabinoid system. As a result, CBG inhibits the effects of CB1 agonists, especially THC, and can interfere with the effects of other cannabinoids. An interaction with CB2 receptors cannot be ruled out either. CBG is said to have immense potential for treating a wide variety of cancers.

As a component of the hemp plant so far less known or studied than CBD or THC, CBG or cannabigerol is moving more and more into the interest of research: More and more studies are published on its effects and the results are more than promising despite its relatively low concentration.

More on CBG

Cannabigerol  (CBG) is a non-psychoactive cannabinoid found in different types of cannabis. It is currently being investigated for its potential pharmacological properties in clinical trials. Since it is present in low concentrations (less than 1%) in most cannabinoids, it is rarely referred to as CBG in relation to other cannabinoids. However, the following fact is all the more astonishing:

According to cannabis expert and anesthetist Dr. Perry Solomon;

Cannabis plants produce cannabigerolic acid (CBGA), the precursor to the three main cannabinoid lines. Special enzymes in the plant break down CBGA and transform it into …

  • Tetrahydrocannabinoleic acid (THCA),
  • Cannabidioic acid (CBDA) and
  • Cannabichromic acid (CBCA).

When exposed to ultraviolet light or heat, these acids turn into THC and CBD.

So far, early studies have provided interesting evidence that CBG can particularly help with colitis, neurodegeneration, and cancer. The similarity to the two big cannabinoids also continues in the effect. Below, we would like to briefly explain the various properties of this little-known cannabinoid.

CBG properties

When we talk about cannabinoids, we especially think of CBD (cannabidiol) and its many benefits; then to THC (tetrahydrocannabinol), which is responsible for the psychoactive effects of cannabis and is illegal in some countries; but much less of CBG (cannabigerol) or CBGA in its acidic form (acid). As with CBD, CBG has no known side effects, it’s legal, non-psychoactive, and non-addicting.

CBG is first and foremost a molecule that occurs naturally in hemp. In fact, it’s the biochemical precursor to other cannabinoids, because, during the plant’s growth phase, various enzymes convert the CBG into other molecules: The CBD only develops from the CBG after a 6-8 week flowering cycle! This explains why it is only present in small quantities in the harvested hemp plants, as it has already been largely converted at the time of ripening. However, these connections also suggest that CBG may be more promising than it seems …

Cannabidiol & Cannabigerol, different but similar

As mentioned earlier, CBG is kind of a precursor to CBD. While both are cannabinoids, they are different compounds within the cannabis plant. They also have a lot in common, although they serve different purposes. Both can probably help to treat different diseases – this is indicated by the still recent study situation and numerous positive experiences.

Both CBG and CBD are not psychoactive, which means that they do not alter your consciousness in such a way that your everyday fitness or mental clarity is impaired. However, what they apparently can do is effectively relieve anxiety and depression.

In this context, it should also be said that CBG, like CBD, can counteract the intoxicating effects of THC. “Studies with CBG show that it activates the CB1 receptor in the same way as CBD, which significantly reduces psycho-activation,” explains Dr. Solomon.

What are the hopes of CBG?

Despite the current boom, research on CBG is still in its infancy – but the first results are very encouraging. Attention: The studies relate to highly administered CBG in its pure form and therefore in no way allow any conclusions to be drawn about the naturally present proportion of CBG in the plant. For example, CBG is believed to inhibit the uptake of GABA ( γ- aminobutyric acid), a neurotransmitter present in our brain, and increase serotonin levels in the brain. This would relax the muscles, prevent insomnia, and most importantly, reduce anxiety and improve mood(antidepressant properties) which would suggest a number of therapeutic uses.

The CBG is also said to have antifungal (against fungi), anti-inflammatory, and antioxidant properties, which would make it possible to combat oxidative stress in the cells and thus the aging of the body or to have an anti-proliferative effect (inhibits the growth of cancer cells). For example, CBG was also tested to fight the SARS virus and it was found to have antibiotic properties even surpassed those of cannabinol and cannabidiol.

Current studies also report the positive effects of CBG in relation to eye disorders. It can, therefore, be assumed that CBG will be talked about much more often in the future!

How do you consume CBG?

Although hemp is often low in CBG when it is mature, the level of CBG can be increased by simple agricultural methods such as choosing the right time to harvest. For example, if hemp is consumed as herbal tea, it also contains small amounts of CBG. It is then possible to enjoy its benefits in combination with the other active ingredients of the plant.

The current state of research on CBG

Dr. Solomon: “We don’t know much about CBG” but “It’s not your ordinary cannabinoid”. Due to the almost one hundred year cannabis ban and the scarcity of this new type of phytocannabinoid, research is still in its infancy, especially at CBG.

Ultimately, the findings on CBD are large to be regarded as congruent. Nevertheless, let’s take a look at six specific studies on CBG as an example:

  • In animal experiments on mice, CBG was able to reduce the inflammation values in inflammatory bowel disease.
  • In a 2015 study on mice, CBG could be attributed to neuroprotective properties.
  • CBG has been shown to block receptors that trigger the growth of cancer cells. Specifically, it was shown in a study that CBG inhibits the growth of colon cancer cells in mice. It contained tumor growth, showing an interesting option for treating colon cancer.
  • A 2017 study showed that CBG was an effective appetite stimulant in rats. Thus, cannabigerol could be a novel non-psychotropic therapy option e.g. B. in muscle wasting and severe weight loss in the late stage of cancer.
  •  CBG was shown to be most effective in inhibiting bladder muscle contractions relative to four other cannabinoids and may be effective in preventing bladder disease.
  • A 1990 study found that “cannabigerol and related cannabinoids may have therapeutic potential for the treatment of glaucoma “.

Our conclusion is that you can try out CBG at your leisure and expect a positive effect on you and your health.

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